Probably without DXVK it won’t work 
Try to use wine-staging or GloriousEggroll engine and this winetricks:
d3dx11_43
d3dcompiler_43
dotnet472
win7
According to protondb / lutris that should get you started, but again - they all must be using DXVK as well, so there’s no guarantee without it.
Still worth a shot!
If you still have more how and why questions - read more carefully here on Linux gaming [Guide] 