Using system wine on rolling distro (well any distro really) is generally a bad idea because:
Wine is EXTREMELY complex software, it tends to break certain games on version updates because of regressions (meaning you fix something and it breaks something else).
It might work for a while, but eventually it will break for almost any game.
So what you should do?
Use specific version of wine in a portable fashion (independent from your system wine version), so it will not change unless you want it to.
Use independent wineprefix for each game.
Just find a wine version that worked good for your game, follow my instruction with simple scripts (you can do it however you like, it’s just a stupid little example while i was in a hurry so people would understand concept) to create prefix and install game, then transfer your game saves from usual ~/.wine prefix and play it as you was before.
Gnome has different compositor (mutter), but i really doubt it have influenced anything.
How do i know?
Using winetricks is very normal practice to install and make problematic games work.
Most likely your issue is caused because by wine update regressions for your game.
The game here do not get installed on the system, rather we have to run it from its extracted folder and from that location only. If I move out that Game.exe from the parent folder, then game will not run.
“winetricks” is being a PITA lately, it just doesn’t work on Debian. Take my word for it. I only need it for the “corefonts”, imagine if I would need it for one miserable game? I have gone as far as backing up the “dot-reg” files and a few other things of the fake C: drive, then copying the same stuff from another installation, because the thing wouldn’t register the “corefonts”. This is not what I had to do for any Arch-based distro LOL. However, when “winetricks” is installed via “pacman” and it’s run, it complains the “upstream” version is newer. This is only FYI.
There are some 32-bit Windows apps like OpenMPT that might need a few libraries installed such as “lib32-portaudio”, separately from Wine. Also you might want to install “wine-gecko” and “wine-mono” because it’s not done for you. Might want to look into all that.
Almost forgot to mention that Debian and Ubuntu make it near impossible to get “wine-gecko” in particular, and when they feel like it “wine-mono” is available. That’s why I would never recommend anything based on them for games, and barely for anything related to music production except 32-bit freeware.
I actually didn’t played the game the the due to schedule and also the little cousin deleted that game folder back then as the folder was named as misc_timepass , for which I begged pardon from Keybreak.
I will go over it in next few days, so then I will be in better position for explaining it.