Testing another game, and due to the results, it looks like it is a particular game problem related since here the performance is way better than before with Medieval Dynasty.
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Well, still try with ReShade it might hack that problem 
But other than that - i’m afraid all you have to do in that case is just read comments on protondb, once it’s get fixed you’ll know 
Or try each new Wine / Proton / GE / TKG engines versions until you find the one
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I’ll try that ReShade technic and see what happens; at least we’re knowing who’s the culprit so far.
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