You cannot do much, because we are speaking about Wine, which is this complex translation layer.
Here is how much support you have for Virtual DJ in Wine:
You can check this thread about using different DE - maybe you could give it a try:
And some config options to play around:
But if I were you, I would focus on why it works so slow in Windows 10… There should not be such a big difference, and if you are into music you will expand your toolset and also you do not want to have unexpected config probems when you will go in front of an audience.
Did you try to install fresh Windows 10 in place of EoS?