There is a bit of an audio delay and sometimes the playback fails. This only happens when I use easyeffects for crystal audio and bass enhancement effects over the pipewire+wireplumber setup on my desktop.
[srpx31@SRPx-PC1 ~]$ inxi -A
Audio:
Device-1: Intel Xeon E3-1200 v3/4th Gen Core Processor HD Audio
driver: snd_hda_intel
Device-2: Intel 8 Series/C220 Series High Definition Audio
driver: snd_hda_intel
API: ALSA v: k6.1.26-1-lts status: kernel-api
Server-1: PipeWire v: 0.3.70 status: active
[srpx31@SRPx-PC1 ~]$ pactl info
Server String: /run/user/1000/pulse/native
Library Protocol Version: 35
Server Protocol Version: 35
Is Local: yes
Client Index: 1181
Tile Size: 65472
Host Name: SRPx-PC1
Server Name: PulseAudio (on PipeWire 0.3.70)
Server Version: 15.0.0
Default Sample Specification: float32le 2ch 48000Hz
Default Channel Map: front-left,front-right
Default Sink: alsa_output.pci-0000_00_1b.0.5.analog-stereo
Default Source: alsa_input.pci-0000_00_1b.0.5.analog-stereo
Cookie: 05d8:4675