Thoughts:
In my experience PlayOnLinux adds layers of bloat, it’s best to avoid it, if you can, in favor of something like pure wine scripts / Lutris in my experience
If you install it that way and create an override, i think it should work
Otherwise i suggest to try with another Wine version, and also your prefix is x86 which tells me you use POL scripts probably, which are pretty outdated usually.
This days it is EXTREMELY rare you need x86 prefix, usually you just install latest x64 Wine version, install game, and then troubleshoot from there if anything gone wrong
[05/15/21 13:04:24] - Running wine-6.5-staging harvey.exe (Working directory : /home/thorsten/.PlayOnLinux/wineprefix/Harvey/drive_c/GOG Games/Edna and Harvey - Harveys New Eyes)
002c:fixme:winediag:LdrInitializeThunk wine-staging 6.5 is a testing version containing experimental patches.
002c:fixme:winediag:LdrInitializeThunk Please mention your exact version when filing bug reports on winehq.org.
00d0:err:winediag:gnutls_initialize failed to load libgnutls, no support for encryption
00d0:err:winediag:gnutls_initialize failed to load libgnutls, no support for pfx import/export
00d0:err:module:open_builtin_file failed to load .so lib “/home/thorsten/.PlayOnLinux/wine/linux-x86/6.5-staging/lib/wine/mp3dmod.dll.so”
wine: configuration in L"/home/thorsten/.PlayOnLinux//wineprefix/Harvey" has been updated.
0024:err:module:open_builtin_file failed to load .so lib “/home/thorsten/.PlayOnLinux/wine/linux-x86/6.5-staging/lib/wine/openal32.dll.so”
0024:err:module:import_dll Loading library OpenAL32.dll (which is needed by L"C:\GOG Games\Edna and Harvey - Harveys New Eyes\harvey.exe") failed (error c000007a).
0024:err:module:LdrInitializeThunk Importing dlls for L"C:\GOG Games\Edna and Harvey - Harveys New Eyes\harvey.exe" failed, status c0000135
Nice catch! Now the intro (Daedalic) is coming up at least, but not yet the main game, and no audio.
[05/15/21 17:31:15] - Running wine- harvey.exe (Working directory : /home/thorsten/.PlayOnLinux/wineprefix/Harvey/drive_c/GOG Games/Edna and Harvey - Harveys New Eyes)
0024:fixme:ver:GetCurrentPackageId (0021F404 00000000): stub
00fc:fixme:service:I_ScRegisterDeviceNotification Notification filters are not yet implemented.
17:31:15: m_gamePath: C:\GOG Games\Edna and Harvey - Harveys New Eyes\data.vis
17:31:15: Serialization finished. Needed time: 63 ms
0024:fixme:gameux:GameExplorerImpl_VerifyAccess (04113088, L"visplayer.exe", 0021F964)
0024:err:winediag:gnutls_initialize Failed to load libgnutls, secure connections will not be available.
0024:err:secur32:SECUR32_initSchannelSP no schannel support, expect problems
0024:err:winediag:check_version ntlm_auth was not found or is outdated. Make sure that ntlm_auth >= 3.0.25 is in your path. Usually, you can find it in the winbind package of your distribution.
0024:err:ntlm:ntlm_LsaApInitializePackage no NTLM support, expect problems
0024:fixme:win:RegisterTouchWindow (00010054 00000003): stub
0024:fixme:wgl:X11DRV_wglChoosePixelFormatARB unused pfAttribFList
0024:fixme:imm:ImmReleaseContext (00010054, 09DC6080): stub
0024:fixme:msctf:ThreadMgr_ActivateEx Unimplemented flags 0x4
0024:fixme:imm:ImeSetCompositionString PROBLEM: This only sets the wine level string
0024:fixme:imm:ImeSetCompositionString Reading string unimplemented
0024:fixme:imm:NotifyIME NI_CLOSECANDIDATE
012c:fixme:ver:GetCurrentPackageId (0492F584 00000000): stub
0134:fixme:ver:GetCurrentPackageId (04DFFF20 00000000): stub
0024:fixme:imm:ImeSetCompositionString PROBLEM: This only sets the wine level string
0024:fixme:imm:ImeSetCompositionString Reading string unimplemented
0024:fixme:imm:NotifyIME NI_CLOSECANDIDATE
Sorry, i’m not sure…Looks like you’re on nouveau, that’s usually not the best driver choice for games, but for this game i don’t think it should matter.