Got eye strain with polaris gpu on archlinux/eos/debian/manjaro. On linux mint i dont have eye strain with generic kernel.
Maybe it is from Displayflickering when Freesync is enabled? Try to deactive it in the menu of your Monitor. Or it could be a blurry image?
Are you using the same DE on all of these? If so maybe check what the settings under display are in Mint and see if they are set the same. If you do think it is the kernel have you tried using the LTS kernel? Other than that I really don’t know. (the more information on what you have tried will save people from trying to guess)
freesync enabled/disabled no difference, and its not blurry image
I am using same DE on those systems, display settings are the same. Regular kernel or lts no difference. Same problem with liquorix/cachy kernel from aur. If i build tkg kernel from kernel.org source then i got eye strain on mint. But if i build tkg kernel from ubuntu source then i dont have eye strain on mint.