Best solution I found is setting up a filter chain in Carla [1] with a gate to cut out the noise floor (in my case a lsp gate with a hysteresis [2]) and deepfilter [3] for all the rest (fans, mouse, keyboard, birds, …).
The disadvantages: It isn’t a one click solution and it probably takes an hour or two of figuring everything out. Also deepfilter is going to consume some CPU cycles.
On the upside: in my experience the quality is much better than NoiseTorch or EasyEffects. You can now use it in every application, not only post production but also e.g. live chatting. It’s easy to add other audio plugins into the chain e.g. if you want gain, a compressor, …
Simple setup with a virtual mic that I connect as source to the actual applications:
