To edit this config file, I have to use sudo and when I try to log in after making this change, this is when i3 fails to log in anymore. To fix that, I have to boot into GNOME and remove the line from the config file.
From another post:
Edit
/usr/share/X11/xorg.conf.d/40-libinput.confAdd there
Option "NaturalScrolling" "True"like this:For your mouse:
# Match on all types of devices but joysticks
Section "InputClass"
Identifier "libinput pointer catchall"
MatchIsPointer "on"
MatchDevicePath "/dev/input/event*"
Driver "libinput"
Option "NaturalScrolling" "True"
EndSection