Eh, it depends? It really depends on your over layout. Generally, you want the root of /home and /home/$USER/.cache on fast storage. So if you are storing your data on slower storage, it is better to keep the root of /home on the faster storage.
Likewise, if the encryption is different between devices, that can cause you to make different decisions.
There shouldn’t be a difference unless the reliability of your underlying devices is different.
I have an SSD for the system (including home) and some “slow” HDDs for data and Wine prefixes, so I was planning to mount the HDDs to their respective directories under /home such as /drive1 and so on. So, if I do this then everything in /home would be on the SSD except for those directories where those extra drives are mounted?